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We use a simple cell population model to study how biological rhythms and the cell cycle interact to modulate the response to cancer therapy. Estimating cell turnover research theme Human tissues continually replace dying lineajre with newborn cells.
Biological processes span several scales in space, from the single molecules to organisms and ecosystems. Chronotherapy of cancer research theme Chronotherapy of cancers aims at exploiting daily physiological rhythms to improve anti-cancer efficacy and tolerance to drugs by administering treatments at a specific time each day.
A better understanding of the dyamical feature of clock regulation is important for designing individualized chronotherapy treatments. Multiscale modelling approaches in biology are useful to take into account the complex interactions between different organisation levels in those systems.
Human tissues continually replace dying cells with newborn cells. Moreover, death, birth and turnover rates can be estimated. A theoretical basis for the rational development of individualized therapy schedules is still lacking. We have developed a mathematical method to estimate cell turnover in slowly renewing biological systems.
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However, the rate of renewal varies by orders of magnitudes between blood cells, which are renewed every day and neurons, for which renewal is non-existent or limited to specific regions of the brain. Chronotherapy of cancers aims at ezercices daily physiological rhythms to improve anti-cancer efficacy and tolerance to drugs by administering treatments at a specific time each day.
Multiscale modelling research theme Biological processes span several scales in space, from the single molecules to organisms exervices ecosystems.
Between those extreme are many tissues that turn over on a time scale of years, although no direct measurements have been done. We are interested in approaches corfigs on master equations for stochastic processes, individual-based models, hybrid continuous-discrete models and structured PDE models.
Recent clinical trials have shown that chronotherapy can be beneficial in improving quality of life and median life span in patients, but that it can also exrecices negative effects if the timing is wrong.
Age distribution of DNA can be estimated from the integration of radiocarbon derived from nuclear bomb testing during For slowly renewing tissues, this method provides a better estimate of the average age of the tissue than direct estimate from the bomb curve.