Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow. The anticancer activity is induced by xanthones such as alpha-, beta-, and gamma-mangostin which are major constituents of the pericarp of mangosteen fruits. In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction.

Author: Samujind Tojabar
Country: Barbados
Language: English (Spanish)
Genre: Environment
Published (Last): 16 July 2006
Pages: 334
PDF File Size: 8.40 Mb
ePub File Size: 10.35 Mb
ISBN: 505-5-71662-195-9
Downloads: 90940
Price: Free* [*Free Regsitration Required]
Uploader: Shaktikus

The cells were then washed twice and resuspended in RPMI medium. April Volume 37 Issue 4. Thus, surgical therapy, radiation and medication in combination are usually used to treat oral cancer; however, severe adverse effects and low treatment efficacy, as alpba as the ineffective inhibition of cancer cell growth and micrometastasis, results in patients with oral cancer tending to have a poor prognosis 5.

International Journal of Molecular Medicine 37, no. Tumor weights in the experimental nude mice were also determined to be 0. A clinicostatistical analysis of oral cancer patients for recent 8 years.

Mangostin | C24H26O6 – PubChem

From the perspective of cell proliferation, cancer cells can be defined as being resistant to cell cycle control In general, if apoptosis is induced in vitro and in vivoan increase majgostin the sub-G1 population is observed along with DNA fragmentation 28 Introduction Cancer is one of the most life-threatening diseases worldwide, and the incidence and mortality of cancer in Korea have continuously increased due to various acquired risk factors, including a Western diet and environmental factors 1.


The Bclregulated apoptotic pathway. In other words, an increase in the proportion of sub-G1 cells reflects an increase in apoptosis.

Caspases are further classified into initiator and effector caspases. CA Cancer J Clin.


All animal experiments were performed following the approval of the Institutional Animal Care and Use Committee according to the guidelines of Kongju National University. The cells treated with DAPI staining was utilized to observe the cells by fluorescence microscopy. Surgical mangostkn, radiation therapies, medications and other current treatments for oral cancer are associated with a low treatment efficacy and severe adverse effects; thus, in general, oral cancer has a poor prognosis.

Anti-inflammatory activity of mangostins from Garcinia mangostana. This article is mentioned in: This is an open access article distributed under the terms of Manfostin Commons Attribution License. Antimicrobial activities of Garcinia mangostana.

Fluorescence signals were visualized using a fluorescence microscope BX41; Olympus Co. The mice were sacrificed by ether inhalation at 22 days following treatment and the tumors were excised for the measurement of tumor weight.

Apoptosis and the cell cycle.

There was a problem providing the content you requested

The animals were housed in cages and allowed access to sterilized water and commercial rodent chow Biopia, Seoul, Korea ad libitum. It has been reported that xanthone, a component contained within the pericarp rind or peel of the mangosteen fruit, has been shown to exert various biological effects, including antioxidant 7anticancer 8antibacterial 910anti-inflammatory 11anti-allergic and antiviral effects Data analysis was performed using ImageJ software by measuring the integrated band densities following background subtraction.


Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia HL cells.


Moreover, the observed increases were concentration-dependent. Statistical significance was determined by the Dunnett’s t-test. Donovan M and Cotter TG: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki To identify cleaved c -caspase-3 protein, immunohistochemcal staining was performed on tumor tissues collected from mouse xenografts as described in the Material and methods.

Both caspase-3 and -9 were activated, as evidenced by the increased levels of the respective cleaved forms, as well as PARP segmentation Fig. B Membranes incubated with the anti-Bcl-2 antibody. Thus, as regards the development of particular anticancer drugs and preventive medications, the extent that a substance affects cancer cell cycle progression should be identified.

Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of mangostih and down-regulation of ERK pathways. Home Submit Manuscript My Account. Change of the invasiveness with selective Cox-2 inhibition in an oral squamous cell carcinoma cell Line, KB: Moreover, the number of viable cells decreased in a concentration-dependent manner.

International Journal of Molecular Medicine, 37,

Subscribe US Now